MyBioSource.com's Anti-KNSTRN Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
SKAP has a role in kinetochore-microtubule interaction for faithful chromosome segregation. KNSTRN (C15orf23, FLJ14502, kinastrin, SKAP, TRAF4AF1) encodes a kinetochore-associated protein that modulates anaphase onset and chromosome segregation during mitosis. It is expressed in a broad range of human tissues, including in skin. The KNSTRN mutation encoding p.Ser24Phe involves a C>T transition that is characteristic of UV-induced mutagenesis. Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs)